Restylane® Refyne and Defyne harness the power of hyaluronic acid to treat facial wrinkles, lines, folds, and volume loss. They are FDA approved and known as some of the safest fillers worldwide. Restylane Refyne and Defyne are flexible fillers that maintain natural expressions and appearances, making them an ideal treatment for areas of the face that see more movement like around the mouth.

Laser & Skin Surgery Center of Pennsylvania serves the greater Philadelphia area on the Main Line in Devon with a comprehensive range of procedures and treatments. Our board-certified dermatologists are experts at administering injectables for flawless and long-lasting results.

Restylane Defyne and Refyne are FDA-approved fillers that are designed to treat facial wrinkles using XpressHAn technology, which enables natural and flexible facial movement and expressions. They use hyaluronic acid to reduce the appearance of smile and laugh lines, with natural, long-lasting results.

Refyne filler targets mild to moderate dynamic wrinkles, which occur from repeated facial expressions like laughing, smiling, and frowning, while Defyne filler treats more severe wrinkles.

A Refyne or Defyne treatment can help:

• Minimize creases, lines, and wrinkles
• Hydrate skin
• Rejuvenate skin
• Plump facial lines
• Improve volume loss
• Improve perceived age

Restylane Refyne and Defyne are injectable fillers that treat lines and wrinkles on the face. Refyne is more effective in treating:

• Dynamic wrinkles like smile and laugh lines
• Unwanted creases in the lower portion of the face
• Mild-to-moderate lines around the nose and mouth

Defyne is more effective in treating:

• Deeper dynamic wrinkles like smile and laugh lines
• Moderate-to-severe lines
• Volume loss

Restylane Refyne and Defyne are most commonly used to treat:

• Nasolabial folds—lines that extend from the nose to the corner of the mouth
• Marionette lines—wrinkles that run from the mouth to the chin
• Smile lines—small vertical lines at the corners of the mouth

Injectable fillers are administered with a small needle or microcannula based on the size of the treatment area and how much filler is needed. Restylane Refyne and Defyne treatments are minimally-invasive and can take up to 30 minutes to administer. Many patients find the treatments painless, but topical numbing cream and other options are available to ensure a positive experience. It is a simple procedure with little to no downtime—patients can resume normal activities immediately after treatment.